Estudio PREDIMED-Plus: Ensayo multicéntrico sobre la Dieta Mediterránea

Efecto de una dieta mediterránea tradicional con restricción de energía, actividad física y tratamiento conductual sobre la prevención de enfermedad cardiovascular.

Actividad física
Obesidad
Diabetes
Alimentación
Salud cardiometabólica
Calidad de vida
Mayores
El proyecto Predimed-Plus se ha convertido en el mayor reto de investigación sobre nutrición realizado en España. En él se evalúa el efecto de una intervención intensiva con objetivos de pérdida de peso, basada en el consumo de dieta mediterránea hipocalórica, promoción de actividad física y terapia conductual en la prevención de enfermedades cardiovasculares. Nuestro grupo coordina la evaluación anual de más de 2000 participantes de este estudio.

Tipo: Proyecto financiado por varios proyectos FIS (ISCIII) y por la Junta de Andalucía (Consejería de Salud y Programa Operativo FEDER 2014-2020).
Duración: 2013 y sigue
Referencia: PI-0458-2013, PI16/00662, PY18-1434, PI19/00386

IP

Colaboradores

Proyectos derivados

Tesis doctorales

Publicaciones

Association of sedentary behavior with atrial fibrillation-related biomarkers in a population with overweight or obesity
Linzi Li, Amit Shah, Yi-An Ko, ... , Alvaro Alonso
medRxiv: The Preprint Server for Health Sciences, 2025.08.25.25334401 (2025)
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Comparison of an Energy-Reduced Mediterranean Diet and Physical Activity Versus an Ad Libitum Mediterranean Diet in the Prevention of Type 2 Diabetes : A Secondary Analysis of a Randomized Controlled Trial
Miguel Ruiz-Canela, Dolores Corella, Miguel Ángel Martínez-González, ... , Julia Wärnberg, ...​ , Jordi Salas-Salvadó
Annals of Internal Medicine, 10, 1378--1389 (2025)
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COVID-19 and Cognitive Decline in Older Adults with High-Cardiovascular Risk: A Post Hoc Analysis
Sangeetha Shyam, Carlos Gómez-Martínez, Jiaqi Ni, ... , Julia Wärnberg, ...​ , Napoleón Pérez-Farinós, ...​​ , Jordi Salas-Salvadó
Aging and disease, 4, 2373--2382 (2025)
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Objectively Measured Sleep Duration and Health-Related Quality of Life in Older Adults with Metabolic Syndrome: A One-Year Longitudinal Analysis of the PREDIMED-Plus Cohort
Alba Marcos-Delgado, Vicente Martín-Sánchez, Miguel Ángel Martínez-González, ... , Julia Wärnberg, ...​ , Francisco Javier Barón-López, ...​​ , Javier Nieto
Nutrients, 16, 2631 (2024)
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More Adult Women than Men at High Cardiometabolic Risk Reported Worse Lifestyles and Self-Reported Health Status in the COVID-19 Lockdown
Alejandro Oncina-Cánovas, Laura Compañ-Gabucio, Jesús Vioque, ... , Julia Wärnberg, ...​ , Olga Fernández-Barceló, ...​​ , Manuela García-de-la-Hera
Nutrients, 13, 2000 (2024)
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How Did the COVID-19 Lockdown Pandemic Affect the Depression Symptomatology in Mediterranean Older Adults with Metabolic Syndrome?
Indira Paz-Graniel, Nancy Babio, Stephanie K. Nishi, ... , Julia Wärnberg, ...​ , Francisco Javier Barón-López, ...​​ , Jordi Salas-Salvadó
Depression and Anxiety, 1--9 (2023)
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Impact of COVID-19 pandemic on the PREDIMED-Plus randomized clinical trial: Effects on the interventions, participants follow-up, and adiposity
Indira Paz-Graniel, Montserrat Fitó, Emilio Ros, ... , Julia Wärnberg, ...​ , Francisco Javier Barón-López, ...​​ , Jordi Salas-Salvadó
Frontiers in Nutrition, 1098269 (2023)
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Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort
Sangeetha Shyam, Jesús Francisco García-Gavilán, Indira Paz-Graniel, ... , Julia Wärnberg, ...​ , Jordi Salas-Salvadó
BMC Medicine, 1, 390 (2023)
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Intensive Weight-Loss Lifestyle Intervention Using Mediterranean Diet and COVID-19 Risk in Older Adults: Secondary Analysis of PREDIMED-Plus Trial
Sangeetha Shyam, J.F. García-Gavilán, I. Paz-Graniel, ... , Jordi Salas-Salvadó
The Journal of nutrition, health and aging, 12, 1162--1167 (2023)
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Tipos de actividad física en personas mayores con obesidad y síndrome metabólico
J.C. Benavente-Marín, J. Pérez-López, E. Crespo-Oliva, N. Pérez-Farinós, Francisco Javier Barón-López, José Carlos Fernández García, J. Wärnberg
Revista Internacional de Medicina y Ciencias de la Actividad Física y del Deporte, 82, 375--388 (2021)
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Neighbourhood walkability and physical activity: moderating role of a physical activity intervention in overweight and obese older adults with metabolic syndrome
Antoni Colom-Fernández, Suzanne Mavoa, Maurici Ruiz, Julia Wärnberg, Josep Muncunill, Jadwiga Konieczna, Guillem Vich, Francisco Javier Barón-López, Montserrat Fitó, Jordi Salas-Salvadó, Dora Romaguera
Age and Ageing, 3, 963--968 (2021)
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Association between ankle-brachial index and cognitive function in participants in the PREDIMED-Plus study: cross-sectional assessment
Meritxell López, Angel Ríos, Dora Romaguera, ... , Edelys Crespo-Oliva, ...​ , Aina M. Yáñez
Revista Espanola De Cardiologia, 10, 846--853 (2021)
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Validation of a modified version of the Spanish Geriatric Oral Health Assessment Index (GOHAI-SP) for adults and elder people
Javiera Aguirre-Bustamante, Francisco Javier Barón-López, Francisco Jesús Carmona-González, Napoleón Pérez-Farinós, Julia Wärnberg
BMC Oral Health, 1, 61 (2020)
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Physical fitness and physical activity association with cognitive function and quality of life: baseline cross-sectional analysis of the PREDIMED-Plus trial
Lidia Daimiel, Miguel A. Martínez-González, Dolores Corella, ... , Julia Wärnberg, ...​ , José M. Ordovás
Scientific Reports, 1, 3472 (2020)
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The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome
Alba Marcos-Delgado, Tania Fernández-Villa, Miguel Ángel Martínez-González, ... , Julia Wärnberg, ...​ , Jessica Pérez-López, ...​​ , Vicente Martín
International Journal of Environmental Research and Public Health, 10, 3728 (2020)
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High sleep variability predicts a blunted weight loss response and short sleep duration a reduced decrease in waist circumference in the PREDIMED-Plus Trial
Christopher Papandreou, Mónica Bulló, Andrés Díaz-López, ... , Napoleón Pérez-Farinós, ...​ , Jordi Salas-Salvadó
International Journal of Obesity, 2, 330--339 (2020)
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Relationship between olive oil consumption and ankle-brachial pressure index in a population at high cardiovascular risk
Cristina Sánchez-Quesada, Estefanía Toledo, Guadalupe González-Mata, ... , Julia Wärnberg, ...​ , Edelys Crespo-Oliva, ...​​ , José J. Gaforio
Atherosclerosis, 48--57 (2020)
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Asociación del consumo máximo de oxígeno con la actividad física y el sedentarismo en el síndrome metabólico. Utilidad de los cuestionarios
Lucas Tojal, Angel Alonso-Gómez, Susana Alberich, Julia Wärnberg, Carolina Sorto, María P. Portillo, Helmut Schröder, Jordi Salas-Salvadó, Fernando Arós
Revista Española de Cardiología, 2, 145--152 (2020)
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Association between maximal oxygen consumption and physical activity and sedentary lifestyle in metabolic syndrome. Usefulness of questionnaires
Lucas Tojal, Angel Alonso-Gómez, Susana Alberich, Julia Wärnberg, Carolina Sorto, María P. Portillo, Helmut Schröder, Jordi Salas-Salvadó, Fernando Arós
Revista Espanola De Cardiologia, 2, 145--152 (2020)
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Mediterranean Built Environment and Precipitation as Modulator Factors on Physical Activity in Obese Mid-Age and Old-Age Adults with Metabolic Syndrome: Cross-Sectional Study
Antoni Colom-Fernández, Maurici Ruiz, Julia Wärnberg, Montserrat Compa, Josep Muncunill, Francisco Javier Barón-López, Juan Carlos Benavente-Marín, Elena Cabeza, Marga Morey, Montserrat Fitó, Jordi Salas-Salvadó, Dora Romaguera
International Journal of Environmental Research and Public Health, 5, 854 (2019)
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Cohort Profile: Design and methods of the PREDIMED-Plus randomized trial
Miguel A Martínez-González, Pilar Buil-Cosiales, Dolores Corella, ... , Julia Wärnberg, ...​ , Jordi Salas-Salvadó
International Journal of Epidemiology, 2, 387--388o (2019)
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Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk
Christopher Papandreou, Nancy Babio, Andrés Díaz-López, ... , Julia Wärnberg, ...​ , Napoleón Pérez-Farinós, ...​​ , Jordi Salas-Salvadó
Nutrients, 4, 761 (2019)
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Effect of a Lifestyle Intervention Program With Energy-Restricted Mediterranean Diet and Exercise on Weight Loss and Cardiovascular Risk Factors: One-Year Results of the PREDIMED-Plus Trial
Jordi Salas-Salvadó, Andrés Díaz-López, Miguel Ruiz-Canela, ... , Julia Wärnberg, ...​ , Miguel Á. Martínez-González
Diabetes Care, 5, 777--788 (2019)
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Effect of a Nutritional and Behavioral Intervention on Energy-Reduced Mediterranean Diet Adherence Among Patients With Metabolic Syndrome: Interim Analysis of the PREDIMED-Plus Randomized Clinical Trial
Carmen Sayón-Orea, Cristina Razquin, Mónica Bulló, ... , Julia Wärnberg, ...​ , Miguel A. Martínez-González
JAMA, 15, 1486 (2019)
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Cross-sectional associations of objectively-measured sleep characteristics with obesity and type 2 diabetes in the PREDIMED-Plus trial
Nuria Rosique-Esteban, Christopher Papandreou, Dora Romaguera, ... , Jordi Salas-Salvadó
Sleep, 12 (2018)
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Changes in fatty liver index after consuming a Mediterranean diet: 6-year follow-up of the PREDIMED-Malaga trial
Raquel Cueto-Galán, Francisco Javier Barón-López, Pedro Valdivielso, Xavier Pintó, Emili Corbella, Enrique Gómez-Gracia, Julia Wärnberg
Medicina Clinica, 10, 435--443 (2017)
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